Structure analysis

Structure of an avian influenza A virus NS1 protein effector domain

X-ray diffraction
1.997Å resolution
Assemblies composition:
homo tetramer
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: homo tetramer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: homo tetramer
Accessible surface area: 24600 Å2
Buried surface area: 3600 Å2
Dissociation area: 1,800 Å2
Dissociation energy (ΔGdiss): 4 kcal/mol
Dissociation entropy (TΔSdiss): 35 kcal/mol
Interface energy (ΔGint): -29 kcal/mol
Symmetry number: 2
Assembly 3 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 12800 Å2
Buried surface area: 1300 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -9 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 158 amino acids
Theoretical weight: 17.75 KDa
Source organism: Influenza A virus (A/duck/Alberta/60/1976(H12N5))
Expression system: Escherichia coli
UniProt:
  • Canonical: P69270 (Residues: 73-230; Coverage: 69%)
Gene name: NS
InterPro:
CATH: Influenza virus non-structural protein, effector domain

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