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Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha)

X-ray diffraction
2.11Å resolution
PDB entry 3d24 coloured by chain, front view.
PDB entry 3d24 coloured by chain, side view.
PDB entry 3d24 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Steroid hormone receptor ERR1 and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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Multimeric state: hetero tetramer
Accessible surface area: 19555.81 Å2
Buried surface area: 5038.62 Å2
Dissociation area: 1,289.71 Å2
Dissociation energy (ΔGdiss): -3.73 kcal/mol
Dissociation entropy (TΔSdiss): 12.99 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145852
Assembly 2 (preferred)
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Assembly Name: Steroid hormone receptor ERR1 and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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Multimeric state: hetero dimer
Accessible surface area: 10851.01 Å2
Buried surface area: 1110.65 Å2
Dissociation area: 555.33 Å2
Dissociation energy (ΔGdiss): 5.27 kcal/mol
Dissociation entropy (TΔSdiss): 7.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145850
Assembly 3
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Assembly Name: Steroid hormone receptor ERR1 and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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Multimeric state: hetero dimer
Accessible surface area: 11284.21 Å2
Buried surface area: 1348.55 Å2
Dissociation area: 674.28 Å2
Dissociation energy (ΔGdiss): 2.92 kcal/mol
Dissociation entropy (TΔSdiss): 8.07 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145850

Macromolecules

Steroid hormone receptor ERR1
Chains: A, C
Length: 253 amino acids
Theoretical weight: 27.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11474 (Residues: 192-423; Coverage: 55%)
Gene names: ERR1, ESRL1, ESRRA, NR3B1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Steroid hormone receptor ERR1 in PDB entry 3d24, assembly 2, front view.
Steroid hormone receptor ERR1 in PDB entry 3d24, assembly 2, side view.
Steroid hormone receptor ERR1 in PDB entry 3d24, assembly 2, top view.
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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Chains: B, D
Length: 22 amino acids
Theoretical weight: 2.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UBK2 (Residues: 198-219; Coverage: 3%)
Gene names: LEM6, PGC1, PGC1A, PPARGC1, PPARGC1A
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha in PDB entry 3d24, assembly 2, front view.
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha in PDB entry 3d24, assembly 2, side view.
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha in PDB entry 3d24, assembly 2, top view.
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