PDBe 3czu

X-ray diffraction
2.65Å resolution

Crystal structure of the human ephrin A2- ephrin A1 complex

Released:
Source organism: Homo sapiens
Primary publication:
Architecture of Eph receptor clusters.
Proc. Natl. Acad. Sci. U.S.A. 107 10860-5 (2010)
PMID: 20505120

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 23.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29317 (Residues: 23-202; Coverage: 19%)
Gene names: ECK, EPHA2
Sequence domains: Ephrin receptor ligand binding domain
Structure domains: Galactose-binding domain-like
Ephrin-A1, secreted form Chain: B
Molecule details ›
Chain: B
Length: 182 amino acids
Theoretical weight: 21.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P20827 (Residues: 17-171; Coverage: 82%)
Gene names: EFNA1, EPLG1, LERK1, TNFAIP4
Sequence domains: Ephrin
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P6522
Unit cell:
a: 99.431Å b: 99.431Å c: 204.879Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.193 0.225
Expression system: Spodoptera frugiperda