PDBe 3cyn

X-ray diffraction
2Å resolution

The structure of human GPX8

Source organism: Homo sapiens
Entry authors: Kavanagh KL, Johansson C, Yue WW, Kochan G, Pike ACW, Murray J, Roos AK, Filippakopoulos P, von Delft F, Arrowsmith CH, Wikstrom M, Edwards AM, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents:
1 distinct polypeptide molecule
Probable glutathione peroxidase 8 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 189 amino acids
Theoretical weight: 21.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8TED1 (Residues: 44-209; Coverage: 79%)
Gene names: GPX8, UNQ847/PRO1785
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 90.688Å b: 120.854Å c: 75.603Å
α: 90° β: 119.38° γ: 90°
R R work R free
0.172 0.171 0.199
Expression system: Escherichia coli BL21(DE3)