Structure analysis

Crystal Structure of Human Spliceosomal U1 snRNP

X-ray diffraction
5.493Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero decamer (preferred)
Entry contents: 9 distinct polypeptide molecules
1 distinct RNA molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero decamer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero decamer

Binding statistics and energies are not available for this assembly
Assembly 3
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Multimeric state: hetero decamer

Binding statistics and energies are not available for this assembly
Assembly 4
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Multimeric state: hetero decamer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: D, S, T, U
Length: 126 amino acids
Theoretical weight: 13.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62318 (Residues: 1-126; Coverage: 100%)
Gene name: SNRPD3
Pfam: LSM domain
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Chains: A, H, I, J
Length: 174 amino acids
Theoretical weight: 18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14678 (Residues: 1-174; Coverage: 73%)
Gene names: COD, SNRPB, SNRPB1
Pfam: LSM domain
InterPro:

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Chains: B, M, N, O
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62314 (Residues: 1-119; Coverage: 100%)
Gene name: SNRPD1
Pfam: LSM domain
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Chains: C, P, Q, R
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62316 (Residues: 1-118; Coverage: 100%)
Gene names: SNRPD1, SNRPD2
Pfam: LSM domain
InterPro:

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Chains: 1, 2, F, Z
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62306 (Residues: 1-86; Coverage: 100%)
Gene names: PBSCF, SNRPF
Pfam: LSM domain
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Chains: E, W, X, Y
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62304 (Residues: 1-92; Coverage: 100%)
Gene name: SNRPE
Pfam: LSM domain
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Chains: 3, 4, 5, G
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62308 (Residues: 1-76; Coverage: 100%)
Gene names: PBSCG, SNRPG
Pfam: LSM domain
InterPro:

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Chains: 0, 9, L, l
Length: 77 amino acids
Theoretical weight: 8.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09234 (Residues: 1-77; Coverage: 48%)
Gene name: SNRPC
Pfam: U1 zinc finger
InterPro:

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Name: U1 snRNA
Representative chains: V, v, w, x
Length: 138 nucleotides
Theoretical weight: 44.42 KDa
Rfam: U1 spliceosomal RNA

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