Structure analysis

The set and ring associated (SRA) domain of UHRF1 bound to methylated DNA

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 13100 Å2
Buried surface area: 3900 Å2
Dissociation area: 1,000 Å2
Dissociation energy (ΔGdiss): 25 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): -18 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly
Assembly 3
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Multimeric state: hetero trimer
Accessible surface area: 12900 Å2
Buried surface area: 3800 Å2
Dissociation area: 1,000 Å2
Dissociation energy (ΔGdiss): 24 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): -17 kcal/mol
Symmetry number: 1
Assembly 4
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D
Length: 212 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96T88 (Residues: 413-617; Coverage: 26%)
Gene names: ICBP90, NP95, RNF106, UHRF1
Pfam: SAD/SRA domain
InterPro:
CATH: SRA-YDG
SCOP: SRA domain-like

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Name: 5'-D(*DGP*DGP*DGP*DCP*DCP*(5CM)P*DGP*DCP*DAP*DGP*DGP*DG)-3'
Representative chains: E, G, I, K
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.74 KDa

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Name: 5'-D(*DCP*DCP*DCP*DTP*DGP*DCP*DGP*DGP*DGP*DCP*DCP*DC)-3'
Representative chains: F, H, J, L
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.6 KDa

Search similar DNA