3cl2

X-ray diffraction
2.54Å resolution

N1 Neuraminidase N294S + Oseltamivir

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 385 amino acids
Theoretical weight: 42.16 KDa
Source organism: Influenza A virus (A/Viet Nam/1203/2004(H5N1))
Expression system: Influenza A virus
UniProt:
  • Canonical: Q6DPL2 (Residues: 63-447; Coverage: 86%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P6
Unit cell:
a: 290.649Å b: 290.649Å c: 133.293Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.239 0.263
Expression system: Influenza A virus