› 3ckx

X-ray diffraction
2.7Å resolution

Crystal structure of sterile 20-like kinase 3 (MST3, STK24) in complex with staurosporine

Released:
DOI: 10.2210/pdb3ckx/pdb
PDB entry 3ckx coloured by chain, front view.
PDB entry 3ckx coloured by chain, side view.
PDB entry 3ckx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Antonysamy SS, Burley SK, Buchanan S, Chau F, Feil I, Wu L, Sauder JM, New York SGX Research Center for Structural Genomics (NYSGXRC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 24 36 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6E0 (Residues: 31-323; Coverage: 66%)
Gene names: MST3, STK24, STK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand STU 1 x STU
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 47.369Å b: 54.766Å c: 61.136Å
α: 90° β: 114.69° γ: 90°
R-values:
R R work R free
0.204 0.204 0.268
Expression system: Escherichia coli

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