3ciy

X-ray diffraction
3.41Å resolution

Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct RNA molecules
Macromolecules (12 distinct):
Toll-like receptor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 697 amino acids
Theoretical weight: 79.63 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q99MB1 (Residues: 28-704; Coverage: 77%)
Gene name: Tlr3
Sequence domains:
Structure domains: Ribonuclease Inhibitor
46-MER Chain: C
Molecule details ›
Chain: C
Length: 46 nucleotides
Theoretical weight: 14.78 KDa
Source organism: Mus musculus
Expression system: Not provided
46-MER Chain: D
Molecule details ›
Chain: D
Length: 46 nucleotides
Theoretical weight: 14.66 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, NDG
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer : NEW Components: NAG, NDG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer : NEW Components: NAG, NDG, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 117.846Å b: 225.877Å c: 259.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.288 0.333
Expression systems:
  • Trichoplusia ni
  • Not provided