X-ray diffraction
2.4Å resolution

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with quercetin


Function and Biology Details

Reaction catalysed:
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 159 amino acids
Theoretical weight: 18.21 KDa
Source organism: Helicobacter pylori
Expression system: Escherichia coli
  • Canonical: Q5G940 (Residues: 1-159; Coverage: 100%)
Gene names: B0X65_07140, BB395_03990, BFR58_03630, D2C76_06245, DD756_07280, DD767_06730, DDP42_00065, EC592_05795, EDA73_06725, HPPMSS1_c00137, fabZ
Sequence domains: FabA-like domain
Structure domains: Hotdog Thioesterase

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 73.987Å b: 100.438Å c: 186.009Å
α: 90° β: 90° γ: 90°
R R work R free
0.193 0.193 0.226
Expression system: Escherichia coli