X-ray diffraction
3.3Å resolution

Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE2865


Function and Biology Details

Reaction catalysed:
((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glycogen phosphorylase, liver form Chains: A, B
Molecule details ›
Chains: A, B
Length: 809 amino acids
Theoretical weight: 93.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P06737 (Residues: 24-832; Coverage: 96%)
Gene name: PYGL
Sequence domains: Carbohydrate phosphorylase
Structure domains: Glycogen Phosphorylase B;

Ligands and Environments

Cofactor: Ligand PLP 2 x PLP
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P31
Unit cell:
a: 123.27Å b: 123.27Å c: 121.88Å
α: 90° β: 90° γ: 120°
R R work R free
0.181 0.176 0.271
Expression system: Spodoptera frugiperda