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Crystal structure of homoserine dehydrogenase from Thermoplasma volcanium

Source organism: Thermoplasma volcanium GSS1
Biochemical function: NADP binding
Biological process: threonine biosynthetic process
Cellular component: not assigned

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EC 1.1.1.3: Homoserine dehydrogenase

Reaction catalysed:
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H
Systematic name:
L-homoserine:NAD(P)(+) oxidoreductase
Alternative Name(s):
  • HSD
  • HSDH

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00742
Domain description: Homoserine dehydrogenase
Occurring in:
  1. homoserine dehydrogenase
The deposited structure of PDB entry 3c8m contains 1 copy of Pfam domain PF00742 (Homoserine dehydrogenase) in homoserine dehydrogenase. Showing 1 copy in chain A.

PF03447
Domain description: Homoserine dehydrogenase, NAD binding domain
Occurring in:
  1. homoserine dehydrogenase
The deposited structure of PDB entry 3c8m contains 1 copy of Pfam domain PF03447 (Homoserine dehydrogenase, NAD binding domain) in homoserine dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001342
Domain description: Homoserine dehydrogenase, catalytic
Occurring in:
  1. homoserine dehydrogenase
IPR005106
Domain description: Aspartate/homoserine dehydrogenase, NAD-binding
Occurring in:
  1. homoserine dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. homoserine dehydrogenase
IPR022697
Domain description: Homoserine dehydrogenase lacking ACT domain
Occurring in:
  1. homoserine dehydrogenase

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. homoserine dehydrogenase
The deposited structure of PDB entry 3c8m contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in homoserine dehydrogenase. Showing 1 copy in chain A.
3.30.360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dihydrodipicolinate Reductase; domain 2
Homology: Dihydrodipicolinate Reductase; domain 2
Occurring in:
  1. homoserine dehydrogenase
The deposited structure of PDB entry 3c8m contains 1 copy of CATH domain 3.30.360.10 (Dihydrodipicolinate Reductase; domain 2) in homoserine dehydrogenase. Showing 1 copy in chain A.

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