3c8m

X-ray diffraction
1.9Å resolution

Crystal structure of homoserine dehydrogenase from Thermoplasma volcanium

Released:
Source organism: Thermoplasma volcanium GSS1
Entry authors: Osipiuk J, Hendricks R, Abdullah J, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed:
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homoserine dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.13 KDa
Source organism: Thermoplasma volcanium GSS1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q97BR6 (Residues: 1-328; Coverage: 100%)
Gene name: TVG0375766
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 108.404Å b: 108.404Å c: 60.458Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.157 0.156 0.177
Expression system: Escherichia coli BL21(DE3)