X-ray diffraction
3.12Å resolution

Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heat shock protein homolog SSE1 Chain: A
Molecule details ›
Chain: A
Length: 668 amino acids
Theoretical weight: 74.54 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P32589 (Residues: 1-666; Coverage: 96%)
Gene names: LPG3C, MSI3, SSE1, YPL106C
Sequence domains: Hsp70 protein
Structure domains:
Heat shock cognate 71 kDa protein Chain: B
Molecule details ›
Chain: B
Length: 554 amino acids
Theoretical weight: 61.08 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P19120 (Residues: 1-554; Coverage: 85%)
Gene names: HSC70, HSPA8
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21212
Unit cell:
a: 123.533Å b: 169.501Å c: 87.724Å
α: 90° β: 90° γ: 90°
R R work R free
0.227 0.224 0.283
Expression system: Escherichia coli BL21(DE3)