EC 1.14.14.24: Vitamin D 25-hydroxylase
Reaction catalysed:
Calciol + O(2) + [reduced NADPH--hemoprotein reductase] = calcidiol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Systematic name:
Calciol,NADPH--hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)
Alternative Name(s):
- CYP2R1
- Vitamin D(2) 25-hydroxylase
- Vitamin D(3) 25-hydroxylase
GO terms
Biochemical function:
- D3 vitamins binding
- metal ion binding
- protein homodimerization activity
- vitamin D3 25-hydroxylase activity
- heme binding
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- steroid hydroxylase activity
- iron ion binding
- monooxygenase activity
Protein family (Pfam)
InterPro annotations
CATH domain
SCOP annotation