X-ray diffraction
2Å resolution

PP2A-specific methylesterase apo form (PME)


Function and Biology Details

Reaction catalysed:
[Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein phosphatase methylesterase 1 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 34.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y570 (Residues: 39-386; Coverage: 82%)
  • Best match: Q9Y570-3 (Residues: 3-84)
Gene names: PME1, PP2593, PPME1, PRO0750
Sequence domains: Alpha/beta hydrolase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P3121
Unit cell:
a: 82.512Å b: 82.512Å c: 90.843Å
α: 90° β: 90° γ: 120°
R R work R free
0.183 0.183 0.22
Expression system: Escherichia coli