Assemblies
Assembly Name:
alpha-thrombin complex and Hirudin-3B'
Multimeric state:
hetero dimer
Accessible surface area:
12383.43 Å2
Buried surface area:
1297.13 Å2
Dissociation area:
648.57
Å2
Dissociation energy (ΔGdiss):
0.62
kcal/mol
Dissociation entropy (TΔSdiss):
7.87
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-133142
Macromolecules
Chain: A
Length: 287 amino acids
Theoretical weight: 33.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Pfam:
InterPro:
SCOP: Eukaryotic proteases
Length: 287 amino acids
Theoretical weight: 33.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
P00734 (Residues: 335-621; Coverage: 48%)
Pfam:
InterPro:
- Thrombin light chain
- Thrombin light chain domain superfamily
- Peptidase S1, PA clan
- Prothrombin/thrombin
- Serine proteases, trypsin domain
- Peptidase S1, PA clan, chymotrypsin-like fold
- Peptidase S1A, chymotrypsin family
- Serine proteases, trypsin family, histidine active site
- Serine proteases, trypsin family, serine active site
SCOP: Eukaryotic proteases
Chain: B
Length: 11 amino acids
Theoretical weight: 1.49 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.49 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
- Canonical: P28511 (Residues: 55-65; Coverage: 17%)
