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Crystal structure of a TetR family transcriptional regulator from Streptomyces coelicolor A3(2)

X-ray diffraction
2.7Å resolution
PDB entry 3c07 coloured by chain, front view.
PDB entry 3c07 coloured by chain, side view.
PDB entry 3c07 coloured by chain, top view.
Source organism: Streptomyces coelicolor A3(2)
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 21329.89 Å2
Buried surface area: 3785.38 Å2
Dissociation area: 1,664.39 Å2
Dissociation energy (ΔGdiss): 25.19 kcal/mol
Dissociation entropy (TΔSdiss): 12.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-192178

Macromolecules

HTH tetR-type domain-containing protein
Chains: A, B
Length: 273 amino acids
Theoretical weight: 31.26 KDa
Source organism: Streptomyces coelicolor A3(2)
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9KZ96 (Residues: 1-251; Coverage: 100%)
Gene names: SC5G8.18c, SCO4850
Pfam:
InterPro:
CATH: Tetracycline Repressor, domain 2
SCOP:
HTH tetR-type domain-containing protein in PDB entry 3c07, assembly 1, front view.
HTH tetR-type domain-containing protein in PDB entry 3c07, assembly 1, side view.
HTH tetR-type domain-containing protein in PDB entry 3c07, assembly 1, top view.
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