X-ray diffraction
2.7Å resolution

Crystal structure of a TetR family transcriptional regulator from Streptomyces coelicolor A3(2)

Entry authors: Tan K, Xu X, Zheng H, Savchenko A, Edwards AM, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Putative tetR-family transcriptional regulator Chains: A, B
Molecule details ›
Chains: A, B
Length: 273 amino acids
Theoretical weight: 31.26 KDa
Source organism: Streptomyces coelicolor A3(2)
Expression system: Escherichia coli BL21
  • Canonical: Q9KZ96 (Residues: 1-251; Coverage: 100%)
Gene name: SCO4850
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P43212
Unit cell:
a: 74.947Å b: 74.947Å c: 208.075Å
α: 90° β: 90° γ: 90°
R R work R free
0.221 0.218 0.289
Expression system: Escherichia coli BL21