› 3bx7

X-ray diffraction
2.1Å resolution

Engineered Human Lipocalin 2 (LCN2) in Complex with the Extracellular Domain of Human CTLA-4

Released:
DOI: 10.2210/pdb3bx7/pdb
PDB entry 3bx7 coloured by chain, front view.
PDB entry 3bx7 coloured by chain, side view.
PDB entry 3bx7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Schonfeld DL, Chatwell L, Skerra A

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147717 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cytotoxic T-lymphocyte protein 4 Chain: C
Molecule details ›
Chain: C
Length: 124 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P16410 (Residues: 38-161; Coverage: 66%)
Gene names: CD152, CTLA4
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
ENGINEERED HUMAN LIPOCALIN 2 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 20.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3221
Unit cell:
a: 120.706Å b: 120.706Å c: 82.957Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.209 0.226
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli str. K-12 substr. W3110

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