› › Function and Biology

Golgi alpha-mannosidase II D341N acid-base catalyst mutant with bound mannose

Source organism: Drosophila melanogaster
Biochemical function: metal ion binding
Biological process: encapsulation of foreign target
Cellular component: membrane

Quick links

EC 3.2.1.114: Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Reaction catalysed:
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose
Systematic name:
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining)
Alternative Name(s):
  • (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase
  • 1,3(1,6)-alpha-D-mannosidase
  • 1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase
  • Alpha-1-3,6-mannosidase
  • Alpha-D-mannosidase II
  • Alpha-mannosidase II
  • Exo-1,3-1,6-alpha-mannosidase
  • GlcNAc transferase I-dependent alpha-1,3(alpha-1,6)mannosidase
  • Golgi alpha-mannosidase II
  • ManII
  • Mannosidase II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF18230
Domain description: Glycosyl hydrolases family 38 C-terminal sub-domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of Pfam domain PF18230 (Glycosyl hydrolases family 38 C-terminal sub-domain) in Alpha-mannosidase 2. Showing 1 copy in chain A.

PF07748
Domain description: Glycosyl hydrolases family 38 C-terminal domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of Pfam domain PF07748 (Glycosyl hydrolases family 38 C-terminal domain) in Alpha-mannosidase 2. Showing 1 copy in chain A.

PF21260
Domain description: Lysosomal alpha-mannosidase-like, central domain
Occurring in:
  1. Alpha-mannosidase 2

PF09261
Domain description: Alpha mannosidase middle domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of Pfam domain PF09261 (Alpha mannosidase middle domain) in Alpha-mannosidase 2. Showing 1 copy in chain A.

PF01074
Domain description: Glycosyl hydrolases family 38 N-terminal domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of Pfam domain PF01074 (Glycosyl hydrolases family 38 N-terminal domain) in Alpha-mannosidase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015341
Domain description: Glycoside hydrolase family 38, central domain
Occurring in:
  1. Alpha-mannosidase 2
IPR041566
Domain description: Alpha-mannosidase 2, C-terminal sub-domain
Occurring in:
  1. Alpha-mannosidase 2
IPR011682
Domain description: Glycosyl hydrolase family 38, C-terminal
Occurring in:
  1. Alpha-mannosidase 2
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Alpha-mannosidase 2
IPR011013
Domain description: Galactose mutarotase-like domain superfamily
Occurring in:
  1. Alpha-mannosidase 2
IPR028995
Domain description: Glycoside hydrolase families 57/38, central domain superfamily
Occurring in:
  1. Alpha-mannosidase 2
IPR037094
Domain description: Glycoside hydrolase family 38, central domain superfamily
Occurring in:
  1. Alpha-mannosidase 2
IPR000602
Domain description: Glycoside hydrolase family 38, N-terminal domain
Occurring in:
  1. Alpha-mannosidase 2
IPR011330
Domain description: Glycoside hydrolase/deacetylase, beta/alpha-barrel
Occurring in:
  1. Alpha-mannosidase 2
IPR027291
Domain description: Glycoside hydrolase 38, N-terminal domain superfamily
Occurring in:
  1. Alpha-mannosidase 2

Structure domains

CATH CATH domains
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Alpha-mannosidase 2. Showing 1 copy in chain A.
2.60.40.1360
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulin-like
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of CATH domain 2.60.40.1360 (Immunoglobulin-like) in Alpha-mannosidase 2. Showing 1 copy in chain A.
2.70.98.30
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Beta-galactosidase; Chain A, domain 5
Homology: Golgi alpha-mannosidase II; domain 4
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of CATH domain 2.70.98.30 (Beta-galactosidase; Chain A, domain 5) in Alpha-mannosidase 2. Showing 1 copy in chain A.
1.20.1270.50
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Substrate Binding Domain Of Dnak; Chain:A; Domain 2
Homology: Glycoside hydrolase family 38, central domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of CATH domain 1.20.1270.50 (Substrate Binding Domain Of Dnak; Chain:A; Domain 2) in Alpha-mannosidase 2. Showing 1 copy in chain A.
3.20.110.10
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: 7-stranded beta/alpha barrel
Homology: Glycoside hydrolase 38, N terminal domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of CATH domain 3.20.110.10 (7-stranded beta/alpha barrel) in Alpha-mannosidase 2. Showing 1 copy in chain A.
SCOP SCOP annotations
88656
Class: All beta proteins
Fold: Supersandwich
Superfamily: Galactose mutarotase-like
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of SCOP domain 88656 (alpha-mannosidase, C-terminal domain) in Alpha-mannosidase 2. Showing 1 copy in chain A.
88693
Class: All alpha proteins
Fold: immunoglobulin/albumin-binding domain-like
Superfamily: Families 57/38 glycoside transferase middle domain
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of SCOP domain 88693 (alpha-mannosidase, domain 2) in Alpha-mannosidase 2. Showing 1 copy in chain A.
88714
Class: Alpha and beta proteins (a/b)
Fold: 7-stranded beta/alpha barrel
Superfamily: Glycoside hydrolase/deacetylase
Occurring in:
  1. Alpha-mannosidase 2
The deposited structure of PDB entry 3bup contains 1 copy of SCOP domain 88714 (alpha-mannosidase) in Alpha-mannosidase 2. Showing 1 copy in chain A.

Quick links