PDBe 3bu5

X-ray diffraction
2.1Å resolution

Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 35.03 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P06213 (Residues: 1005-1310; Coverage: 23%)
Gene name: INSR
Sequence domains: Protein tyrosine kinase
Structure domains:
Insulin receptor substrate 2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.72 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: P81122 (Residues: 620-634; Coverage: 1%)
Gene name: Irs2

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 46.75Å b: 84.428Å c: 50.601Å
α: 90° β: 112.88° γ: 90°
R R work R free
0.196 0.194 0.239
Expression systems:
  • Spodoptera frugiperda
  • Not provided