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NEMO/IKKb association domain structure

X-ray diffraction
2.2Å resolution
PDB entry 3brv coloured by chain, front view.
PDB entry 3brv coloured by chain, side view.
PDB entry 3brv coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Inhibitor of nuclear factor kappa-B kinase subunit beta and NF-kappa-B essential modulator
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Multimeric state: hetero tetramer
Accessible surface area: 11520.63 Å2
Buried surface area: 8704.83 Å2
Dissociation area: 2,698.18 Å2
Dissociation energy (ΔGdiss): 50.99 kcal/mol
Dissociation entropy (TΔSdiss): 12.47 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127200
Assembly 2 (preferred)
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Assembly Name: Inhibitor of nuclear factor kappa-B kinase subunit beta and NF-kappa-B essential modulator
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Multimeric state: hetero dimer
Accessible surface area: 8338.37 Å2
Buried surface area: 1779.2 Å2
Dissociation area: 889.6 Å2
Dissociation energy (ΔGdiss): 10.93 kcal/mol
Dissociation entropy (TΔSdiss): 9.89 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127198
Assembly 3
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Assembly Name: Inhibitor of nuclear factor kappa-B kinase subunit beta and NF-kappa-B essential modulator
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Multimeric state: hetero dimer
Accessible surface area: 8391.84 Å2
Buried surface area: 1716.06 Å2
Dissociation area: 858.03 Å2
Dissociation energy (ΔGdiss): 10.52 kcal/mol
Dissociation entropy (TΔSdiss): 10.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127198
Assembly 4
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Assembly Name: Inhibitor of nuclear factor kappa-B kinase subunit beta and NF-kappa-B essential modulator
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Multimeric state: hetero dimer
Accessible surface area: 8111.39 Å2
Buried surface area: 1878.26 Å2
Dissociation area: 939.13 Å2
Dissociation energy (ΔGdiss): 10.57 kcal/mol
Dissociation entropy (TΔSdiss): 9.93 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127198
Assembly 5
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Assembly Name: Inhibitor of nuclear factor kappa-B kinase subunit beta and NF-kappa-B essential modulator
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Multimeric state: hetero dimer
Accessible surface area: 8320.06 Å2
Buried surface area: 1915.75 Å2
Dissociation area: 957.88 Å2
Dissociation energy (ΔGdiss): 9.96 kcal/mol
Dissociation entropy (TΔSdiss): 10.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127198

Macromolecules

Inhibitor of nuclear factor kappa-B kinase subunit beta
Chains: A, C
Length: 48 amino acids
Theoretical weight: 5.44 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14920 (Residues: 701-745; Coverage: 6%)
Gene names: IKBKB, IKKB
Pfam: I-kappa-kinase-beta NEMO binding domain
InterPro: I-kappa-kinase-beta NEMO binding domain
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Inhibitor of nuclear factor kappa-B kinase subunit beta in PDB entry 3brv, assembly 2, front view.
Inhibitor of nuclear factor kappa-B kinase subunit beta in PDB entry 3brv, assembly 2, side view.
Inhibitor of nuclear factor kappa-B kinase subunit beta in PDB entry 3brv, assembly 2, top view.
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NF-kappa-B essential modulator
Chains: B, D
Length: 70 amino acids
Theoretical weight: 8.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6K9 (Residues: 44-111; Coverage: 16%)
Gene names: FIP3, IKBKG, NEMO
Pfam: NF-kappa-B essential modulator NEMO
InterPro: NF-kappa-B essential modulator NEMO, N-terminal
CATH: L1 transposable element, trimerization domain
NF-kappa-B essential modulator in PDB entry 3brv, assembly 2, front view.
NF-kappa-B essential modulator in PDB entry 3brv, assembly 2, side view.
NF-kappa-B essential modulator in PDB entry 3brv, assembly 2, top view.
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