› 3bqk

X-ray diffraction
1.8Å resolution

Structure of a chondroitin sulphate binding DBL3X from a var2csa encoded PfEMP1 protein in complex with sulphate

Released:
DOI: 10.2210/pdb3bqk/pdb
PDB entry 3bqk coloured by chain, front view.
PDB entry 3bqk coloured by chain, side view.
PDB entry 3bqk coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
The structure of a chondroitin sulfate-binding domain important in placental malaria.
Higgins MK
J Biol Chem 283 21842-6 (2008)
PMID: 18550531

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180411 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythrocyte membrane protein 1 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 41.16 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6UDW7 (Residues: 1218-1577; Coverage: 12%)
Gene name: var
Sequence domains: Duffy binding domain
Structure domains: Duffy-antigen binding domain

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 41.258Å b: 86.555Å c: 92.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.231 0.286
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Malaria parasite proteins that remodel the host erythrocyte.
Maier et al. (2009)
15 more

11 mentions without citation

The structure of a chondroitin sulfate-binding domain important in placental malaria.
Higgins MK. (2008)
10 more