3bo7

X-ray diffraction
2.35Å resolution

Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136

Released:
Entry authors: Wernimont AK, Lew J, Kozieradzki I, Lin YH, Sun X, Khuu C, Zhao Y, Schapira M, Arrowsmith CH, Edwards AM, Weigelt J, Bochkarev A, Hui R, Artz JD, Xiao T, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 201 amino acids
Theoretical weight: 23.21 KDa
Source organism: Toxoplasma gondii
Expression system: Escherichia coli
UniProt:
  • Canonical: D0VWS5 (Residues: 1-201; Coverage: 100%)
Gene name: 541.m00136
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
CYCLOSPORIN A Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: C2
Unit cell:
a: 149.631Å b: 100.805Å c: 86.184Å
α: 90° β: 116.28° γ: 90°
R-values:
R R work R free
0.192 0.19 0.245
Expression systems:
  • Escherichia coli
  • Not provided