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Crystal Structure of M11, the BCL-2 Homolog of Murine Gamma-herpesvirus 68, Complexed with Mouse Beclin1 (residues 106-124)

Source organisms:
Biochemical function: not assigned
Biological process: regulation of apoptotic process
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF15285
Domain description: Beclin-1 BH3 domain, Bcl-2-interacting
Occurring in:
  1. Beclin-1
The deposited structure of PDB entry 3bl2 contains 2 copies of Pfam domain PF15285 (Beclin-1 BH3 domain, Bcl-2-interacting) in Beclin-1. Showing 1 copy in chain C.

PF15286
Domain description: Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like
Occurring in:
  1. Apoptosis regulator Bcl-2 homolog
The deposited structure of PDB entry 3bl2 contains 2 copies of Pfam domain PF15286 (Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like) in Apoptosis regulator Bcl-2 homolog. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036834
Domain description: Bcl-2-like superfamily
Occurring in:
  1. Apoptosis regulator Bcl-2 homolog
IPR029318
Domain description: Beclin-1, BH3 domain
Occurring in:
  1. Beclin-1
IPR029450
Domain description: Apoptosis regulator M11
Occurring in:
  1. Apoptosis regulator Bcl-2 homolog

Structure domain

CATH CATH domain
1.10.437.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Apoptosis Regulator Bcl-x
Homology: Blc2-like
Occurring in:
  1. Apoptosis regulator Bcl-2 homolog
The deposited structure of PDB entry 3bl2 contains 2 copies of CATH domain 1.10.437.10 (Apoptosis Regulator Bcl-x) in Apoptosis regulator Bcl-2 homolog. Showing 1 copy in chain A.
SCOP SCOP annotation
56855
Class: Membrane and cell surface proteins and peptides
Fold: Toxins' membrane translocation domains
Superfamily: Bcl-2 inhibitors of programmed cell death
Occurring in:
  1. Apoptosis regulator Bcl-2 homolog
The deposited structure of PDB entry 3bl2 contains 2 copies of SCOP domain 56855 (Bcl-2 inhibitors of programmed cell death) in Apoptosis regulator Bcl-2 homolog. Showing 1 copy in chain A.

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