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Crystal structure of Pseudomonas aeruginosa phosphoheptose isomerase

Source organism: Pseudomonas aeruginosa PAO1
Biochemical function: carbohydrate derivative binding
Biological process: D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Cellular component: cytoplasm

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EC 5.3.1.28: D-sedoheptulose-7-phosphate isomerase

Reaction catalysed:
D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate
Systematic name:
D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase
Alternative Name(s):
  • GmhA
  • LpcA
  • Phosphoheptose isomerase
  • Sedoheptulose-7-phosphate isomerase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13580
Domain description: SIS domain
Occurring in:
  1. Phosphoheptose isomerase
The deposited structure of PDB entry 3bjz contains 4 copies of Pfam domain PF13580 (SIS domain) in Phosphoheptose isomerase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001347
Domain description: SIS domain
Occurring in:
  1. Phosphoheptose isomerase
IPR035461
Domain description: GmhA/DiaA
Occurring in:
  1. Phosphoheptose isomerase
IPR046348
Domain description: SIS domain superfamily
Occurring in:
  1. Phosphoheptose isomerase
IPR004515
Domain description: Phosphoheptose isomerase
Occurring in:
  1. Phosphoheptose isomerase

Structure domain

CATH CATH domain
3.40.50.10490
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glucose-6-phosphate isomerase like protein; domain 1
Occurring in:
  1. Phosphoheptose isomerase
The deposited structure of PDB entry 3bjz contains 4 copies of CATH domain 3.40.50.10490 (Rossmann fold) in Phosphoheptose isomerase. Showing 1 copy in chain B.
SCOP SCOP annotation
69599
Class: Alpha and beta proteins (a/b)
Fold: SIS domain
Superfamily: SIS domain
Occurring in:
  1. Phosphoheptose isomerase
The deposited structure of PDB entry 3bjz contains 4 copies of SCOP domain 69599 (mono-SIS domain) in Phosphoheptose isomerase. Showing 1 copy in chain B.

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