X-ray diffraction
2.5Å resolution

Pyruvate kinase M2 is a phosphotyrosine binding protein

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 530 amino acids
Theoretical weight: 57.86 KDa
Source organism: Homo sapiens
  • Canonical: P14618 (Residues: 2-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 74.634Å b: 80.707Å c: 107.597Å
α: 69.82° β: 77.74° γ: 67.97°
R R work R free
0.211 0.211 0.271