X-ray diffraction
1.44Å resolution

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
PNP_UDP_1 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 349 amino acids
Theoretical weight: 38 KDa
Source organism: Trypanosoma brucei
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q57VZ2 (Residues: 1-341; Coverage: 100%)
Gene name: Tb927.8.4430
Sequence domains: Phosphorylase superfamily
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 63.015Å b: 95.387Å c: 63.483Å
α: 90° β: 105.91° γ: 90°
R R work R free
0.156 0.155 0.184
Expression system: Escherichia coli BL21(DE3)