› 3bj4

X-ray diffraction
2Å resolution

The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction

Released:
DOI: 10.2210/pdb3bj4/pdb
PDB 3bj4 coloured by chain and viewed from the front.
PDB 3bj4 coloured by chain and viewed from the side.
PDB 3bj4 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction.
Wiener R, Haitin Y, Shamgar L, Fernández-Alonso MC, Martos A, Chomsky-Hecht O, Rivas G, Attali B, Hirsch JA
J Biol Chem 283 5815-30 (2008)
PMID: 18165683

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily KQT member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 49 amino acids
Theoretical weight: 5.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51787 (Residues: 574-622; Coverage: 7%)
Gene names: KCNA8, KCNA9, KCNQ1, KVLQT1

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 51.321Å b: 51.321Å c: 71.094Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.221 0.255
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Atomistic Insights of Calmodulin Gating of Complete Ion Channels.
Núñez et al. (2020)
18 more

3 mentions without citation

The Crossroad of Ion Channels and Calmodulin in Disease.
Urrutia et al. (2019)
2 more