X-ray diffraction
2.22Å resolution

Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
3-hydroxy-3-methylglutaryl-coenzyme A reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 441 amino acids
Theoretical weight: 47.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P04035 (Residues: 441-875; Coverage: 49%)
Gene name: HMGCR
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P21
Unit cell:
a: 71.588Å b: 172.156Å c: 75.148Å
α: 90° β: 117.24° γ: 90°
R R work R free
0.21 0.208 0.251
Expression system: Escherichia coli