X-ray diffraction
2.3Å resolution

[E296Q]LTA4H in complex with Arg-Ala-Arg substrate


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Leukotriene A-4 hydrolase Chain: A
Molecule details ›
Chain: A
Length: 616 amino acids
Theoretical weight: 70.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P09960 (Residues: 2-611; Coverage: 100%)
Gene names: LTA4, LTA4H
Sequence domains:
Structure domains:
RAR peptide Chain: B
Molecule details ›
Chain: B
Length: 3 amino acids
Theoretical weight: 403 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P212121
Unit cell:
a: 78.49Å b: 87.785Å c: 99.916Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.206 0.273
Expression systems:
  • Escherichia coli
  • Not provided