X-ray diffraction
1.88Å resolution

Lovastatin polyketide enoyl reductase (LovC) complexed with 2'-phosphoadenosyl isomer of crotonoyl-CoA


Function and Biology Details

Reaction catalysed:
9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Lovastatin nonaketide synthase, enoyl reductase component lovC Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 40.62 KDa
Source organism: Aspergillus terreus
Expression system: Escherichia coli
  • Canonical: Q9Y7D0 (Residues: 1-363; Coverage: 100%)
Gene name: lovC
Sequence domains: Alcohol dehydrogenase GroES-like domain
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 44.334Å b: 54.867Å c: 171.82Å
α: 90° β: 90° γ: 90°
R R work R free
0.176 0.171 0.221
Expression system: Escherichia coli