PDBe 3b4v

X-ray diffraction
2.48Å resolution

X-Ray structure of Activin in complex with FSTL3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Inhibin beta A chain Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Follistatin-related protein 3 Chains: C, D, G, H
Molecule details ›
Chains: C, D, G, H
Length: 237 amino acids
Theoretical weight: 24.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95633 (Residues: 27-263; Coverage: 100%)
Gene names: FLRG, FSTL3, UNQ674/PRO1308
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 63.613Å b: 71.384Å c: 100.203Å
α: 98.55° β: 90.64° γ: 90.11°
R-values:
R R work R free
0.229 0.227 0.279
Expression system: Homo sapiens