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Crystal Structure Analysis of Chitinase A from Vibrio harveyi with novel inhibitors - W275G mutant complex structure with PENTOXIFYLLINE

Source organism: Vibrio harveyi
Biochemical function: chitin binding
Biological process: chitin catabolic process
Cellular component: not assigned

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EC 3.2.1.14: Chitinase

Reaction catalysed:
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins
Systematic name:
(1->4)-2-acetamido-2-deoxy-beta-D-glucan glycanohydrolase
Alternative Name(s):
  • 1,4-beta-poly-N-acetylglucosaminidase
  • Beta-1,4-poly-N-acetyl glucosamidinase
  • ChiC
  • Chitodextrinase
  • Poly(1,4-(N-acetyl-beta-D-glucosaminide)) glycanohydrolase
  • Poly-beta-glucosaminidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00704
Domain description: Glycosyl hydrolases family 18
Occurring in:
  1. GH18 domain-containing protein
The deposited structure of PDB entry 3aru contains 1 copy of Pfam domain PF00704 (Glycosyl hydrolases family 18) in GH18 domain-containing protein. Showing 1 copy in chain A.

PF08329
Domain description: Chitinase A, N-terminal domain
Occurring in:
  1. GH18 domain-containing protein
The deposited structure of PDB entry 3aru contains 1 copy of Pfam domain PF08329 (Chitinase A, N-terminal domain) in GH18 domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029070
Domain description: Chitinase insertion domain superfamily
Occurring in:
  1. GH18 domain-containing protein
IPR001223
Domain description: Glycoside hydrolase family 18, catalytic domain
Occurring in:
  1. GH18 domain-containing protein
IPR001579
Domain description: Glycosyl hydrolases family 18 (GH18) active site
Occurring in:
  1. GH18 domain-containing protein
IPR011583
Domain description: Chitinase II
Occurring in:
  1. GH18 domain-containing protein
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. GH18 domain-containing protein
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. GH18 domain-containing protein
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. GH18 domain-containing protein
IPR013540
Domain description: Chitinase A N-terminal
Occurring in:
  1. GH18 domain-containing protein

Structure domains

CATH CATH domains
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. GH18 domain-containing protein
The deposited structure of PDB entry 3aru contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in GH18 domain-containing protein. Showing 1 copy in chain A.
3.10.50.10
Class: Alpha Beta
Architecture: Roll
Topology: Chitinase A; domain 3
Homology: Chitinase A; domain 3
Occurring in:
  1. GH18 domain-containing protein
The deposited structure of PDB entry 3aru contains 1 copy of CATH domain 3.10.50.10 (Chitinase A; domain 3) in GH18 domain-containing protein. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. GH18 domain-containing protein
The deposited structure of PDB entry 3aru contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in GH18 domain-containing protein. Showing 1 copy in chain A.

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