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Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose

X-ray diffraction
2.33Å resolution
PDB entry 3ap4 coloured by chain, front view.
PDB entry 3ap4 coloured by chain, side view.
PDB entry 3ap4 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Galectin-8
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Multimeric state: monomeric
Accessible surface area: 7624.92 Å2
Buried surface area: 594.53 Å2
Dissociation area: 237.55 Å2
Dissociation energy (ΔGdiss): -3.82 kcal/mol
Dissociation entropy (TΔSdiss): 4.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126160
Assembly 2
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Assembly Name: Galectin-8
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Multimeric state: monomeric
Accessible surface area: 7633.24 Å2
Buried surface area: 600.87 Å2
Dissociation area: 240.44 Å2
Dissociation energy (ΔGdiss): -3.28 kcal/mol
Dissociation entropy (TΔSdiss): 4.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126160
Assembly 3
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Assembly Name: Galectin-8
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Multimeric state: monomeric
Accessible surface area: 7781.51 Å2
Buried surface area: 597.67 Å2
Dissociation area: 238.48 Å2
Dissociation energy (ΔGdiss): -4.45 kcal/mol
Dissociation entropy (TΔSdiss): 4.21 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126160
Assembly 4
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Assembly Name: Galectin-8
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Multimeric state: monomeric
Accessible surface area: 7661.57 Å2
Buried surface area: 600.9 Å2
Dissociation area: 239.72 Å2
Dissociation energy (ΔGdiss): -4.49 kcal/mol
Dissociation entropy (TΔSdiss): 4.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126160

Macromolecules

Galectin-8
Chains: A, B, C, D
Length: 154 amino acids
Theoretical weight: 17.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00214 (Residues: 1-154; Coverage: 49%)
Gene name: LGALS8
Pfam: Galactoside-binding lectin
InterPro:
CATH: Jelly Rolls
Galectin-8 in PDB entry 3ap4, assembly 1, front view.
Galectin-8 in PDB entry 3ap4, assembly 1, side view.
Galectin-8 in PDB entry 3ap4, assembly 1, top view.
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