3aig

X-ray diffraction
2.8Å resolution

ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL656

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, and 16-Tyr-|-Leu-17 of insulin B chain.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase adamalysin-2 Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 23.15 KDa
Source organism: Crotalus adamanteus
UniProt:
  • Canonical: P34179 (Residues: 2-203; Coverage: 100%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P3212
Unit cell:
a: 73.55Å b: 73.55Å c: 96.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.194 not available