EC 2.7.11.11: cAMP-dependent protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (cAMP-dependent)
Alternative Name(s):
- PKA
- PKA C
- Protein kinase A
- STK22
GO terms
Biochemical function:
- protein serine kinase activity
- channel activator activity
- protein kinase A regulatory subunit binding
- ubiquitin protein ligase binding
- manganese ion binding
- protein domain specific binding
- protein kinase binding
- ATP binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- cAMP-dependent protein kinase activity
- AMP-activated protein kinase activity
- protein serine/threonine kinase activity
- protein kinase activity
- magnesium ion binding
Biological process:
- regulation of bicellular tight junction assembly
- protein localization to lipid droplet
- negative regulation of glycolytic process through fructose-6-phosphate
- negative regulation of TORC1 signaling
- regulation of cardiac conduction
- postsynaptic modulation of chemical synaptic transmission
- cell communication by electrical coupling involved in cardiac conduction
- cellular response to epinephrine stimulus
- cellular response to glucagon stimulus
- cellular response to parathyroid hormone stimulus
- cellular response to glucose stimulus
- regulation of protein processing
- cellular response to cold
- regulation of proteasomal protein catabolic process
- regulation of cardiac muscle contraction
- regulation of cell cycle
- positive regulation of calcium-mediated signaling
- modulation of chemical synaptic transmission
- sperm capacitation
- positive regulation of protein export from nucleus
- negative regulation of smoothened signaling pathway
- positive regulation of gluconeogenesis
- regulation of osteoblast differentiation
- mitochondrial protein catabolic process
- cellular response to heat
- high-density lipoprotein particle assembly
- negative regulation of interleukin-2 production
- positive regulation of insulin secretion
- cytokine-mediated signaling pathway
- peptidyl-serine phosphorylation
- regulation of macroautophagy
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- protein kinase A signaling
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- protein export from nucleus
- protein phosphorylation
- mRNA processing
- renal water homeostasis
- regulation of heart rate
- neural tube closure
- mesoderm formation
Cellular component:
- glutamatergic synapse
- ciliary base
- extracellular exosome
- perinuclear region of cytoplasm
- plasma membrane raft
- dendritic spine
- sperm flagellum
- calcium channel complex
- neuromuscular junction
- motile cilium
- cytoplasmic vesicle
- nuclear speck
- cAMP-dependent protein kinase complex
- axoneme
- plasma membrane
- cytosol
- centrosome
- mitochondrial matrix
- mitochondrion
- cytoplasm
- nucleoplasm
- nucleus
- acrosomal vesicle
Sequence family
Protein family (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.200.20
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Phosphorylase Kinase; domain 1
Homology:
Phosphorylase Kinase; domain 1
Occurring in:
