3adl

X-ray diffraction
2.2Å resolution

Structure of TRBP2 and its molecule implications for miRNA processing

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
RISC-loading complex subunit TARBP2 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 9.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15633 (Residues: 161-231; Coverage: 19%)
Gene names: TARBP2, TRBP
Sequence domains: Double-stranded RNA binding motif
Structure domains: Double Stranded RNA Binding Domain
RNA (5'-R(P*CP*GP*CP*GP*CP*GP*CP*GP*CP*G)-3') Chains: B, C
Molecule details ›
Chains: B, C
Length: 10 nucleotides
Theoretical weight: 3.21 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: I212121
Unit cell:
a: 55.3Å b: 60.425Å c: 99.892Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.263 0.261 0.298
Expression systems:
  • Escherichia coli
  • Not provided