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Structure of WRN RQC domain bound to double-stranded DNA

X-ray diffraction
1.9Å resolution
PDB entry 3aaf coloured by chain, front view.
PDB entry 3aaf coloured by chain, side view.
PDB entry 3aaf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 16108.86 Å2
Buried surface area: 4350.35 Å2
Dissociation area: 1,433.7 Å2
Dissociation energy (ΔGdiss): 12.21 kcal/mol
Dissociation entropy (TΔSdiss): 22.07 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-116061

Macromolecules

Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Chains: A, B
Length: 134 amino acids
Theoretical weight: 15.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14191 (Residues: 949-1079; Coverage: 9%)
Gene names: RECQ3, RECQL2, WRN
Pfam: RQC domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN in PDB entry 3aaf, assembly 1, front view.
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN in PDB entry 3aaf, assembly 1, side view.
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN in PDB entry 3aaf, assembly 1, top view.
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DNA chains C, D
Name: DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3')
Representative chains: C, D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 14 nucleotides
Theoretical weight: 4.28 KDa
DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3') in PDB entry 3aaf, assembly 1, front view.
DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3') in PDB entry 3aaf, assembly 1, side view.
DNA (5'-D(*AP*CP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*GP*T)-3') in PDB entry 3aaf, assembly 1, top view.
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