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Crystal structure of the human VDR ligand binding domain bound to the synthetic agonist compound 2alpha-methyl-AMCR277A(C23S)

X-ray diffraction
1.72Å resolution
PDB entry 3a3z coloured by chain, front view.
PDB entry 3a3z coloured by chain, side view.
PDB entry 3a3z coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Vitamin D3 receptor
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Multimeric state: monomeric
Accessible surface area: 12658.67 Å2
Buried surface area: 330.19 Å2
Dissociation area: 81.01 Å2
Dissociation energy (ΔGdiss): 12.56 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145848

Macromolecules

Vitamin D3 receptor
Chain: X
Length: 263 amino acids
Theoretical weight: 29.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11473 (Residues: 118-427; Coverage: 61%)
Gene names: NR1I1, VDR
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Vitamin D3 receptor in PDB entry 3a3z, assembly 1, front view.
Vitamin D3 receptor in PDB entry 3a3z, assembly 1, side view.
Vitamin D3 receptor in PDB entry 3a3z, assembly 1, top view.
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