› › Function and Biology

Crystal Structure of the DNMT3A ADD domain

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.1.1.37: DNA (cytosine-5-)-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Systematic name:
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
Alternative Name(s):
  • Cytosine 5-methyltransferase
  • Cytosine DNA methylase
  • Cytosine DNA methyltransferase
  • Cytosine-specific DNA methyltransferase
  • DNA 5-cytosine methylase
  • DNA cytosine C(5) methylase
  • DNA cytosine c(5) methylase
  • DNA cytosine methylase
  • DNA methylase
  • DNA methyltransferase
  • DNA transmethylase
  • DNA-cytosine 5-methylase
  • DNA-cytosine methyltransferase
  • Deoxyribonucleate methylase
  • Deoxyribonucleate methyltransferase
  • Deoxyribonucleic (cytosine-5-)-methyltransferase
  • Deoxyribonucleic acid (cytosine-5-)-methyltransferase
  • Deoxyribonucleic acid methylase
  • Deoxyribonucleic acid methyltransferase
  • Deoxyribonucleic acid modification methylase
  • Deoxyribonucleic methylase
  • EcoRI methylase
  • HpaII methylase
  • HpaII' methylase
  • M.BsuRIa
  • M.BsuRIb
  • Methylphosphotriester-DNA methyltransferase
  • Modification methylase
  • Restriction-modification system
  • Site-specific DNA-methyltransferase (cytosine-specific)
  • Typ II DNA methylase
  • Type II DNA methylase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF21255
Domain description: DNMT3, ADD PHD zinc finger
Occurring in:
  1. DNA (cytosine-5)-methyltransferase 3A
The deposited structure of PDB entry 3a1a contains 1 copy of Pfam domain PF21255 (DNMT3, ADD PHD zinc finger) in DNA (cytosine-5)-methyltransferase 3A. Showing 1 copy in chain A.

PF17980
Domain description: Cysteine rich ADD domain in DNMT3
Occurring in:
  1. DNA (cytosine-5)-methyltransferase 3A
The deposited structure of PDB entry 3a1a contains 1 copy of Pfam domain PF17980 (Cysteine rich ADD domain in DNMT3) in DNA (cytosine-5)-methyltransferase 3A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011011
Domain description: Zinc finger, FYVE/PHD-type
Occurring in:
  1. DNA (cytosine-5)-methyltransferase 3A
IPR044108
Domain description: DNA (cytosine-5)-methyltransferase 3A, ADD domain
Occurring in:
  1. DNA (cytosine-5)-methyltransferase 3A
IPR025766
Domain description: ADD domain
Occurring in:
  1. DNA (cytosine-5)-methyltransferase 3A
IPR040552
Domain description: DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
Occurring in:
  1. DNA (cytosine-5)-methyltransferase 3A

Quick links