3a1a

X-ray diffraction
2.3Å resolution

Crystal Structure of the DNMT3A ADD domain

Released:

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA (cytosine-5)-methyltransferase 3A Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6K1 (Residues: 476-614; Coverage: 15%)
Gene name: DNMT3A

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P6122
Unit cell:
a: 57.581Å b: 57.581Å c: 138.949Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.209 0.25
Expression system: Escherichia coli BL21(DE3)