X-ray diffraction
1.57Å resolution

Crystal Structure of Keap1 in Complex with the N-terminal region of the Nrf2 transcription factor


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chains: A, L
Molecule details ›
Chains: A, L
Length: 311 amino acids
Theoretical weight: 34.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: Q9Z2X8 (Residues: 321-609; Coverage: 46%)
Gene names: Inrf2, Keap1, Kiaa0132
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller
Nuclear factor erythroid 2-related factor 2 Chains: B, M
Molecule details ›
Chains: B, M
Length: 35 amino acids
Theoretical weight: 4.33 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q60795 (Residues: 17-51; Coverage: 6%)
Gene names: Nfe2l2, Nrf2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21
Unit cell:
a: 66.138Å b: 84.394Å c: 69.818Å
α: 90° β: 116.89° γ: 90°
R R work R free
0.189 0.187 0.223
Expression systems:
  • Escherichia coli
  • Not provided