PDBe 3wk8

X-ray diffraction
2.2Å resolution

Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor

Released:

Function and Biology Details

Reactions catalysed:
An epoxide + H(2)O = a glycol
(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional epoxide hydrolase 2 Chain: A
Molecule details ›
Chain: A
Length: 561 amino acids
Theoretical weight: 63.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P34913 (Residues: 1-555; Coverage: 100%)
Gene name: EPHX2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P6522
Unit cell:
a: 92.473Å b: 92.473Å c: 243.935Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.254
Expression system: Escherichia coli