3w55

X-ray diffraction
3Å resolution

The structure of ERK2 in complex with FR148083

Released:
Source organism: Homo sapiens
Primary publication:
Role of a cysteine residue in the active site of ERK and the MAPKK family.
Biochem. Biophys. Res. Commun. 353 633-7 (2007)
PMID: 17194451

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 42.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P212121
Unit cell:
a: 43.87Å b: 71.24Å c: 120.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.277 0.26 0.281
Expression system: Escherichia coli