X-ray diffraction
1.57Å resolution

Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2


Function and Biology Details

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ankyrin repeat family A protein 2 Chain: A
Molecule details ›
Chain: A
Length: 167 amino acids
Theoretical weight: 18.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9H9E1 (Residues: 148-313; Coverage: 53%)
Gene names: ANKRA, ANKRA2
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain
Histone deacetylase 4 Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 1.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P56524 (Residues: 343-359; Coverage: 2%)
Gene names: HDAC4, KIAA0288

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 29.663Å b: 52.822Å c: 51.556Å
α: 90° β: 98.01° γ: 90°
R R work R free
0.176 0.174 0.204
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided