X-ray diffraction
1.85Å resolution

Crystal structure of RFXANK


Function and Biology Details

Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
Non-polymer only dimer (preferred)
Non-polymer only tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA-binding protein RFXANK Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 18.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O14593 (Residues: 90-260; Coverage: 66%)
  • Best match: O14593-3 (Residues: 92-238)
Gene names: ANKRA1, RFXANK, RFXB
Sequence domains: Ankyrin repeat
Structure domains: Ankyrin repeat-containing domain
Histone deacetylase 4 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P56524 (Residues: 343-359; Coverage: 2%)
Gene names: HDAC4, KIAA0288

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 43.598Å b: 98.354Å c: 99.358Å
α: 90° β: 90° γ: 90°
R R work R free
0.188 0.187 0.222
Expression systems:
  • Escherichia coli
  • Not provided