PDBe 3uih

X-ray diffraction
2.4Å resolution

crystal structure of human Survivin in complex with Smac/DIABLO(1-15) peptide


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Baculoviral IAP repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 143 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O15392 (Residues: 1-142; Coverage: 100%)
Gene names: API4, BIRC5, IAP4
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Diablo homolog, mitochondrial Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 15 amino acids
Theoretical weight: 1.55 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9NR28 (Residues: 56-70; Coverage: 6%)
Gene names: DIABLO, SMAC

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 114.246Å b: 71.308Å c: 81.095Å
α: 90° β: 127.49° γ: 90°
R R work R free
0.211 0.209 0.245
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided