PDBe 3ugl

X-ray diffraction
1.36Å resolution

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase C delta


Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein kinase C delta type regulatory subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 65 amino acids
Theoretical weight: 7.38 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P28867 (Residues: 231-280; Coverage: 7%)
Gene names: Pkcd, Prkcd
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 43.876Å b: 32.522Å c: 49.816Å
α: 90° β: 94.02° γ: 90°
R R work R free
0.148 0.147 0.17
Expression system: Escherichia coli